DEVLIN TEXTBOOK BIOCHEMISTRY PDF

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—daily tech on the manga guide to calculus. “The art is fantastic, and the teaching method is both Fundamentals of Physics Textbook. 1, Pages· · Page iii. Textbook of Biochemistry with Clinical Correlations: Fourth Edition. Edited by. Thomas M. Devlin, Ph.D. Professor Emeritus. Department of Biochemistry. Textbook of Biochemistry with Clinical Correlations Edited by Thomas M Devlin. pp John Wiley & Sons, New York. £ ISBN 0 - 4 7 1.


Devlin Textbook Biochemistry Pdf

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5-DEVLIN'S Textbook of Biochemistry with Clinical computerescue.info ehab Aboueladab. This document is currently being converted. Please check back in a few. Request PDF on ResearchGate | On Jul 1, , James Zimmerman and others published Textbook of biochemistry: With clinical correlations. by Thomas M. Devlin January A comprehensive and fully updated edition filled with over clinical correlations This book Textbook of Biochemistry with Clinical Correlations, 7th Edition PDF MB Password: computerescue.info Help.

And much of it will, after all, appear in other required coursework of the medical or biology student.

The editor suggests that this book could serve as an upper division or graduate-level biochemistry text. For students in these courses the book has some advantages and some major deficiencies. To me the major advantages are its clear presentation of the biochemistry of a single organism, particularly regulation and control, and the constant attention to correlating particular pathways to specific tissues.

I feel that most students are better served by gaining an integrated understanding of the workings of a single complete system, than they are by being inundated by scattered facts dealing with a myriad of organisms.

I also feel it is important for students to realize that tissues in eukaryotes are specialized, in biochemistry as well as function, and that biochemical integration often comes only at the whole organism level. I was also impressed with the various authors' concern that purported processes have been shown to occur under physiological conditions and at physiological concentrations.

How often in the past have we created fallacious models based on unrealistic in vitro experiments? The major deficiencies of this text are a complete lack of plant biochemistry, including photosynthesis, and the various important pathways lacking in humans, such as essential amino acid biosynthesis and vitamin biosynthesis. For the nonmedical student this is important stuff. Most students, including medical students, would also benefit from problems at the ends of the chapters.

Overall I recommend this book as a medical school text and as an excellent reference. It has been very useful to me in preparing my own lectures for undergraduates. Richard A Paselk Convincing preclinical medical students of the importance of a sound grounding in basic biochemistry for understanding human disease and clinical medicine is often very difficult with the currently available biochemical textbooks.

Thomas Devlin and his twentyone co-authors aimed to produce a textbook for medical students in which biochemical events at the cellular level are related to physiological processes in the whole animal and the relevance of topics to disease problems is emphasised throughout. These correlations cover a considerable range, describing the biochemistry of disease states, biochemical actions of antibiotics and drugs and use of biochemical tests in diagnosis.

Often the same clinical condition, eg diabetes, thalassaemia, gout, is used to illustrate different points in separate chapters. This approach is attractive and for the most part these correlations succeed, but there are some surprising omissions and others are rather contrived.

Besides the clinical correlations there are other useful features particularly welcome for medical s t u d e n t s - the sections on metabolic interrelationships, nutrition, metabolism of individual tissues, pH regulation, gas transport and genetic engineering.

The basic biochemistry is sound and well-written, except for one or two chapters, and there is adequate crossreferencing. However, while this is an attractive book for medical students there are defects.

Generally there is too much detail for British preclinical courses. The photographs and diagrams black-and-white only compare unfavourably with competing biochemistry books and the Index could be better for such a complex book where many topics cut across several sections. If the proposed paper-bound edition January is very substantially cheaper, then it will be worth downloading. S J Higgins himself into the sort of muddle considered reprehensible in an undergraduate biochemistry student.

The next paragraph tells us that a plot of reaction rate against substrate concentration allows the rate constants to be determined, but unfortunately the method of achieving this useful and remarkable feat is not given.

I have concentrated on the small part of the book that is concerned with what I know most about, because I feel that if a book cannot give a clear and accurate account of what I know already it is unwise to trust what it says about anything else.

Perhaps the author is stronger on thermodynamics than on kinetics, but I doubt it. It is not obvious, for example, that he has noticed that most biological processes occur at constant pressure in the liquid phase, rather than at constant volume in the gas phase. So when enthalpy and the Gibbs energy are mentioned at all they are treated as an afterthought and not as quantities that are central to the whole subject. The book is proudly described as a 'second, corrected and updated edition', though it contains virtually no references to modern experimental work in biology or biochemistry and refers, for example, to the unit membrane model of Danielli and Davson as 'generally accepted'.

What the book must have been like before it was updated beggars the imagination. Springer-Verlag, Berlin.

DM This book is intended for both physicists and nonphysicists, but I think that most biochemists will learn nothing from it and that physicists interested in applying their knowledge to biological systems would do better to learn something about biological systems first. When they have done so they will not need this book. Biophysics is a discipline that I approach with caution, because too often it seems to be a refuge for inadequate physicists who see themselves as missionaries among the head-hunters of humbler sciences.

Although I can understand little of what they write, when I do understand I often find incorrect or trivial ideas lurking in the thickets of pretentious mathematics. The first detailed section of the book is devoted to MichaelisMenten kinetics, a topic most biochemists are reasonably familiar with, but Schnakenberg's treatment is not illuminating. The general obscurity is partly the result of using unfamiliar and sometimes undefined symbolism, and I wonder what advantage J has over v as a symbol for reaction rate, for example.

Textbook of Biochemistry with Clinical Correlations, 7th Edition

The failure to explain things adequately in the text is more important, as is the number of elementary errors. I really enjoyed these chapters.

They are rather light on detailed chemistry and enzyme mechanisms, but they are excellent for metabolic regulation, pathway localization and metabolic variations of tissues. The consistent discussion of regulation in a single organism, man, is truly a strong point.

Many texts present regulatory features from a variety of organisms, which I often find confusing and even educationally counterproductive. There are, after all, many optimal ways to regulate a complex system such as a living organism. To understand the principles and applications of regulatory concepts it is better to see how a single system operates, then one can carry over to other systems.

Many texts also tend to gloss over tissue differences. Dr Devlin's book is refreshing in consistently pointing out these differences. Thus discussion of glycolysis includes a lovely figure illustrating glucose metabolism in RBCs, brain, muscle, adipose ceils, and liver parenchymal ceils.

Textbook of biochemistry with clinical correlations

Knowledge of these tissue variations gives a qualitatively different and expanded perspective of the metabolism of the whole organism, versus the naive view which can arise from many texts.

The instructor can also use some of the 'Clinical Correlations' to demonstrate aspects of regulation, tissue variability etc. My students were amazed to see how the interrelatedness of biochemical systems leads to the final consequences of Fructose Intolerance. Thus chapter 14 discusses tissue interrelationships during various metabolic states, while chapters 15 and 16 discuss the biochemistry of various hormones, including their biosynthesis and modes of action.

DNA, RNA, protein biosynthesis and genetic regulation are given a thorough and, to the extent possible in these rapidlydeveloping fields, up-to-date treatment in four chapters. Both prokaryotic and eukaryotic systems are treated, a necessary inconsistency compared to the rest of the book, but a requirement to give an adequate treatment of these topics. These first 20 chapters constitute an essentially complete biochemistry text.

However there are an additional six chapters covering some aspects of physiological chemistry: These chapters vary considerably in biochemical content. There is little new here, but it is convenient.

On the other hand there is much new biochemistry in the chapter on iron and heme metabolism. Though I found the information in these chapters interesting, I must ask whether they are necessary in a text already pages long without this material. And much of it will, after all, appear in other required coursework of the medical or biology student.

The editor suggests that this book could serve as an upper division or graduate-level biochemistry text. For students in these courses the book has some advantages and some major deficiencies. To me the major advantages are its clear presentation of the biochemistry of a single organism, particularly regulation and control, and the constant attention to correlating particular pathways to specific tissues.

I feel that most students are better served by gaining an integrated understanding of the workings of a single complete system, than they are by being inundated by scattered facts dealing with a myriad of organisms. I also feel it is important for students to realize that tissues in eukaryotes are specialized, in biochemistry as well as function, and that biochemical integration often comes only at the whole organism level.

I was also impressed with the various authors' concern that purported processes have been shown to occur under physiological conditions and at physiological concentrations. How often in the past have we created fallacious models based on unrealistic in vitro experiments? The major deficiencies of this text are a complete lack of plant biochemistry, including photosynthesis, and the various important pathways lacking in humans, such as essential amino acid biosynthesis and vitamin biosynthesis.

For the nonmedical student this is important stuff. Most students, including medical students, would also benefit from problems at the ends of the chapters.

Overall I recommend this book as a medical school text and as an excellent reference. It has been very useful to me in preparing my own lectures for undergraduates. Richard A Paselk Convincing preclinical medical students of the importance of a sound grounding in basic biochemistry for understanding human disease and clinical medicine is often very difficult with the currently available biochemical textbooks. Thomas Devlin and his twentyone co-authors aimed to produce a textbook for medical students in which biochemical events at the cellular level are related to physiological processes in the whole animal and the relevance of topics to disease problems is emphasised throughout.

These correlations cover a considerable range, describing the biochemistry of disease states, biochemical actions of antibiotics and drugs and use of biochemical tests in diagnosis. Often the same clinical condition, eg diabetes, thalassaemia, gout, is used to illustrate different points in separate chapters.

This approach is attractive and for the most part these correlations succeed, but there are some surprising omissions and others are rather contrived. Besides the clinical correlations there are other useful features particularly welcome for medical s t u d e n t s - the sections on metabolic interrelationships, nutrition, metabolism of individual tissues, pH regulation, gas transport and genetic engineering. The basic biochemistry is sound and well-written, except for one or two chapters, and there is adequate crossreferencing.

However, while this is an attractive book for medical students there are defects. Generally there is too much detail for British preclinical courses. The photographs and diagrams black-and-white only compare unfavourably with competing biochemistry books and the Index could be better for such a complex book where many topics cut across several sections. If the proposed paper-bound edition January is very substantially cheaper, then it will be worth downloading. S J Higgins himself into the sort of muddle considered reprehensible in an undergraduate biochemistry student.

The next paragraph tells us that a plot of reaction rate against substrate concentration allows the rate constants to be determined, but unfortunately the method of achieving this useful and remarkable feat is not given.

I have concentrated on the small part of the book that is concerned with what I know most about, because I feel that if a book cannot give a clear and accurate account of what I know already it is unwise to trust what it says about anything else.

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Perhaps the author is stronger on thermodynamics than on kinetics, but I doubt it.Richard A Paselk Convincing preclinical medical students of the importance of a sound grounding in basic biochemistry for understanding human disease and clinical medicine is often very difficult with the currently available biochemical textbooks. The consistent discussion of regulation in a single organism, man, is truly a strong point.

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This approach maintains the primary focus of the biochemistry text. The instructor can also use some of the 'Clinical Correlations' to demonstrate aspects of regulation, tissue variability etc. So when enthalpy and the Gibbs energy are mentioned at all they are treated as an afterthought and not as quantities that are central to the whole subject. Close Send. Report This. The book is proudly described as a 'second, corrected and updated edition', though it contains virtually no references to modern experimental work in biology or biochemistry and refers, for example, to the unit membrane model of Danielli and Davson as 'generally accepted'.

There is little new here, but it is convenient.

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